For example, the Wnt/-catenin pathway is involved in BBB integrity, synapse assembly, synapse functions, synaptic plasticity, neurogenesis, white matter lesion remyelination, dopamine neuron neuronal survival protection, and regeneration, whereas aberrations in the Wnt/-catenin pathway are associated with synaptic loss, BBB breakdown, and neurodegenerative disease, including Alzheimers and Parkinsons disease (6468)
Severe mitochondrial dysfunction leads to ATP depletion, oxidative bursts, and apoptosis or nonapoptotic forms of cell death such as necroptosis and ferroptosis [45]
PDHA1 knockdown significantly suppressed tumor growth and enhanced the therapeutic effects of Enz, as evidenced by decreased tumor volume and weight (Fig
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2022;17(11):1-15 CrossRef Kahn HS, Bullard KM, Barker LE